Effects of psychosis-associated genetic markers on brain volumetry: a systematic review of replicated findings and an independent validation.

ABSTRACT:

Background

Given psychotic illnesses' high heritability and associations with brain structure, numerous neuroimaging-genetics findings have been reported in the last two decades. However, few findings have been replicated. In the present independent sample we aimed to replicate any psychosis-implicated SNPs (single nucleotide polymorphisms), which had previously shown at least two main effects on brain volume.

Methods

A systematic review for SNPs showing a replicated effect on brain volume yielded 25 studies implicating seven SNPs in five genes. Their effect was then tested in 113 subjects with either schizophrenia, bipolar disorder, 'at risk mental state' or healthy state, for whole-brain and region-of-interest (ROI) associations with grey and white matter volume changes, u

SUBMITTER: Vouga Ribeiro N 

PROVIDER: S-EPMC9811278 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature