TRPM1 promotes tumor progression in acral melanoma by activating the Ca²⁺/CaMKIIδ/AKT pathway.

ABSTRACT:

Introduction

Acral melanoma is a predominant and aggressive subtype of melanoma in non-Caucasian populations. There is a lack of genotype-driven therapies for over 50% of patients. TRPM1 (transient receptor potential melastatin 1), a nonspecific cation channel, is mainly expressed in retinal bipolar neurons and skin. Nonetheless, the function of TRPM1 in melanoma progression is poorly understood.

Objectives

We investigated the association between TRPM1 and acral melanoma progression and revealed the molecular mechanisms by which TRPM1 promotes tumor progression and malignancy.

Methods

TRPM1 expression and CaMKII phosphorylation in tumor specimens were tested by immunohistochemistry analysis and scored by two independent investigators. The functions of TRPM1 and CaMKII

SUBMITTER: Hsieh CC 

PROVIDER: S-EPMC9811324 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature