Apolipoprotein E e4 allele status and later-life depression in the Lothian Birth Cohort 1936.

ABSTRACT:

Background

Previous results have been mixed regarding the role of the apolipoprotein E e4 (APOE e4) allele in later-life depression: some studies note that carriers experience greater symptoms and increased risk while others find no such association. However, there are few prospective, population-based studies of the APOE e4-depression association and fewer that examine depressive symptom trajectory and depression risk longitudinally. We examined the association between APOE e4 allele status and longitudinal change in depressive symptoms and depression risk in later-life, over a 12-year follow-up period.

Methods

We used data from 690 participants of the Lothian Birth Cohort 1936 who took part in the Scottish Mental Survey 1947 (aged 11) and were followed-up in later-life ove

SUBMITTER: Iveson MH 

PROVIDER: S-EPMC9811345 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature