Charge-reversible and biodegradable chitosan-based microgels for lysozyme-triggered release of vancomycin.

ABSTRACT:

Introduction

High-dose drug administration for the conventional treatment of inflammatory bowel disease induces cumulative toxicity and serious side effects. Currently, few reports have introduced smart carriers for intestinal inflammation targeting toward the treatment of inflammatory bowel disease.

Objectives

For the unique lysozyme secretory microenvironment of the inflamed intestine, vancomycin-loaded chitosan-polyaniline microgels (CH-PANI MGs) were constructed for lysozyme-triggered VM release.

Methods

Aniline was first grafted to chitosan to form polymers that were crosslinked by glutaraldehyde to achieve CH-PANI MGs using the inverse (water-in-oil) miniemulsion method. Interestingly, CH-PANI MGs exhibit polyampholyte behaviour and display charge-reversible beh

SUBMITTER: Li X 

PROVIDER: S-EPMC9811367 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature