Roles of oral microbiota and oral-gut microbial transmission in hypertension.

ABSTRACT:

Introduction

Considerable evidence has linked periodontitis (PD) to hypertension (HTN), but the nature behind this connection is unclear. Dysbiosis of oral microbiota leading to PD is known to aggravate different systematic diseases, but the alteration of oral microbiota in HTN and their impacts on blood pressure (BP) remains to be discovered.

Objectives

To characterize the alterations of oral and gut microbiota and their roles in HTN.

Methods

We performed a cross-sectional (95 HTN participants and 39 controls) and a 6-month follow-up study (52 HTN participants and 26 controls) to analyze the roles of oral and gut microbiota in HTN. Saliva, subgingival plaques, and feces were collected for 16S rRNA gene sequencing or metagenomic analysis. C57BL/6J mice were pretreated

SUBMITTER: Chen BY 

PROVIDER: S-EPMC9811375 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature