Dataset Information

Roles of oral microbiota and oral-gut microbial transmission in hypertension.

ABSTRACT:

Introduction

Considerable evidence has linked periodontitis (PD) to hypertension (HTN), but the nature behind this connection is unclear. Dysbiosis of oral microbiota leading to PD is known to aggravate different systematic diseases, but the alteration of oral microbiota in HTN and their impacts on blood pressure (BP) remains to be discovered.

Objectives

To characterize the alterations of oral and gut microbiota and their roles in HTN.

Methods

We performed a cross-sectional (95 HTN participants and 39 controls) and a 6-month follow-up study (52 HTN participants and 26 controls) to analyze the roles of oral and gut microbiota in HTN. Saliva, subgingival plaques, and feces were collected for 16S rRNA gene sequencing or metagenomic analysis. C57BL/6J mice were pretreated with antibiotics to deplete gut microbiota, and then transplanted with human saliva by gavage to test the impacts of abnormal oral-gut microbial transmission on HTN.

Results

BP in participants with PD was higher than no PD in both cross-sectional and follow-up cohort. Relative abundances of 14 salivary genera, 15 subgingival genera and 10 gut genera significantly altered in HTN and those of 7 salivary genera, 12 subgingival genera and 6 gut genera significantly correlated with BP. Sixteen species under 5 genera were identified as oral-gut transmitters, illustrating the presence of oral-gut microbial transmission in HTN. Veillonella was a frequent oral-gut transmitter stably enriched in HTN participants of both cross-sectional and follow-up cohorts. Saliva from HTN participants increased BP in hypertensive mice. Human saliva-derived Veillonella successfully colonized in mouse gut, more abundantly under HTN condition.

Conclusions

PD and oral microbiota are strongly associated with HTN, likely through oral-gut transmission of microbes. Ectopic colonization of saliva-derived Veillonella in the gut may aggravate HTN. Therefore, precise manipulations of oral microbiota and/or oral-gut microbial transmission may be useful strategies for better prevention and treatment of HTN.

SUBMITTER: Chen BY

PROVIDER: S-EPMC9811375 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Roles of oral microbiota and oral-gut microbial transmission in hypertension.

Chen Bo-Yan BY Lin Wen-Zhen WZ Li Yu-Lin YL Bi Chao C Du Lin-Juan LJ Liu Yuan Y Zhou Lu-Jun LJ Liu Ting T Xu Shuo S Shi Chao-Ji CJ Zhu Hong H Wang Yong-Li YL Sun Jian-Yong JY Liu Yan Y Zhang Wu-Chang WC Lu Hai-Xia HX Wang Yi-Hua YH Feng Qiang Q Chen Fu-Xiang FX Wang Chang-Qian CQ Tonetti Maurizio S MS Zhu Ya-Qin YQ Zhang Huili H Duan Sheng-Zhong SZ

Journal of advanced research 20220319

<h4>Introduction</h4>Considerable evidence has linked periodontitis (PD) to hypertension (HTN), but the nature behind this connection is unclear. Dysbiosis of oral microbiota leading to PD is known to aggravate different systematic diseases, but the alteration of oral microbiota in HTN and their impacts on blood pressure (BP) remains to be discovered.<h4>Objectives</h4>To characterize the alterations of oral and gut microbiota and their roles in HTN.<h4>Methods</h4>We performed a cross-sectional ...[more]

PMID: 36585105

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Dataset Information

Roles of oral microbiota and oral-gut microbial transmission in hypertension.

Introduction

Objectives

Methods

Results

Conclusions

Publications

Roles of oral microbiota and oral-gut microbial transmission in hypertension.

Similar Datasets

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