Novel MRI deformation-heterogeneity radiomic features are associated with molecular subgroups and overall survival in pediatric medulloblastoma: Preliminary findings from a multi-institutional study.

ABSTRACT:

Introduction

Medulloblastoma (MB) is a malignant, heterogenous brain tumor. Advances in molecular profiling have led to identifying four molecular subgroups of MB (WNT, SHH, Group 3, Group 4), each with distinct clinical behaviors. We hypothesize that (1) aggressive MB tumors, growing heterogeneously, induce pronounced local structural deformations in the surrounding parenchyma, and (b) these local deformations as captured on Gadolinium (Gd)-enhanced-T1w MRI are independently associated with molecular subgroups, as well as overall survival in MB patients.

Methods

In this work, a total of 88 MB studies from 2 institutions were analyzed. Following tumor delineation, Gd-T_1w scan for every patient was registered to a normal age-specific T_1w-MRI template via

SUBMITTER: Iyer S 

PROVIDER: S-EPMC9811390 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature