Atopic Dermatitis Mediates the Association Between an IL4RA Variant and Food Allergy in School-Aged Children.

ABSTRACT:

Background

Atopic dermatitis (AD) and food allergy (FA) may share genetic risk factors. It is unknown whether genetic factors directly cause FA or are mediated through AD, as the dual-allergen hypothesis suggests.

Objective

To test the hypothesis that AD mediates the relationship between an IL-4 receptor alpha chain gene (IL4RA) variant, the human IL-4 receptor alpha chain protein-R576 polymorphism, and FA.

Methods

A total of 433 children with asthma enrolled in the School Inner-City Asthma Study underwent genotyping for the IL4RA⁵⁷⁶ allele. Surveys were administered to determine FA, AD, and associated allergic responses. Mediation analysis was performed adjusting for race and ethnicity, age, sex, and household income. Multivariate models were used to deter

SUBMITTER: Banzon TM 

PROVIDER: S-EPMC9811396 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature