Self-Assembly of Immune Signals to Program Innate Immunity through Rational Adjuvant Design.

ABSTRACT: Recent clinical studies show activating multiple innate immune pathways drives robust responses in infection and cancer. Biomaterials offer useful features to deliver multiple cargos, but add translational complexity and intrinsic immune signatures that complicate rational design. Here a modular adjuvant platform is created using self-assembly to build nanostructured capsules comprised entirely of antigens and multiple classes of toll-like receptor agonists (TLRas). These assemblies sequester TLR to endolysosomes, allowing programmable control over the relative signaling levels transduced through these receptors. Strikingly, this combinatorial control of innate signaling can generate divergent antigen-specific responses against a particular antigen. These assemblies drive reorganization of

SUBMITTER: Bookstaver ML 

PROVIDER: S-EPMC9811447 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature