Facile Synthesis of Weakly Ferromagnetic Organogadolinium Macrochelates-Based T₁ -Weighted Magnetic Resonance Imaging Contrast Agents.

ABSTRACT: To surmount the major concerns of commercial small molecule Gd chelates and reported Gd-based contrast agents (GBCAs) for magnetic resonance imaging (MRI), a new concept of organogadolinium macrochelates (OGMCs) constructed from the coordination between Gd³⁺ and macromolecules is proposed. A library of macromolecules were screened for Gd³⁺ coordination, and two candidates [i.e., poly(acrylic acid) (PAA), and poly(aspartic acid) (PASP)] succeeded in OGMC formation. Under optimized synthesis conditions, both Gd-PAA12 and Gd-PASP11 OGMCs are outstanding T₁ -weighted CAs owing to their super high r₁ values (> 50 mm^-1  s^-1 , 3.0 T) and ultralow r₂ /r₁ ratios (< 1.6, 3.0 T). The ferromagnetism of OGMCs is com

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9811448 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature