Electrochemical radical-mediated selective C(sp³)-S bond activation.

ABSTRACT: Selective C(sp³)-S bond breaking and transformation remains a particularly important, yet challenging goal in synthetic chemistry. Over the past few decades, transition metal-catalyzed cross-coupling reactions through the cleavage of C(sp³)-S bonds provided a powerful platform for the construction of target molecules. In contrast, the selective activation of widespread C(sp³)-S bonds is rarely studied and remains underdeveloped, even under relatively harsh conditions. Herein, a radical-mediated electrochemical strategy capable of selectively activating C(sp³)-S bonds is disclosed, offering an unprecedented method for the synthesis of valuable disulfides from widespread thioethers. Importantly, compared with conventional transition-metal catalyzed

SUBMITTER: Li Y 

PROVIDER: S-EPMC9811493 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature