Emulating nonribosomal peptides with ribosomal biosynthetic strategies.

ABSTRACT: Peptide natural products are important lead structures for human drugs and many nonribosomal peptides possess antibiotic activity. This makes them interesting targets for engineering approaches to generate peptide analogues with, for example, increased bioactivities. Nonribosomal peptides are produced by huge mega-enzyme complexes in an assembly-line like manner, and hence, these biosynthetic pathways are challenging to engineer. In the past decade, more and more structural features thought to be unique to nonribosomal peptides were found in ribosomally synthesised and posttranslationally modified peptides as well. These streamlined ribosomal pathways with modifying enzymes that are often promiscuous and with gene-encoded precursor proteins that can be modified easily, offer several advant

SUBMITTER: Mordhorst S 

PROVIDER: S-EPMC9811515 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature