Photocatalytic enantioselective Minisci reaction of β-carbolines and application to natural product synthesis.

ABSTRACT: A highly efficient enantioselective direct C-H functionalization of β-carbolines via a Minisci-type radical process under a photo-redox and chiral phosphoric acid cooperative catalytic system has been disclosed. Through this protocol, a wide range of C1 aminoalkylated β-carbolines were constructed directly with high levels of enantioselectivities from readily available β-carbolines and alanine-derived redox-active esters. This transformation allows straightforward access to highly valuable enantioenriched β-carbolines, which are an intriguing structural motif in valuable natural products and synthetic bio-active compounds. This protocol has been utilized as a highly efficient synthetic strategy for the concise asymmetric total synthesis of marine alkaloids eudistomin X, (+)-eudistom

SUBMITTER: Luo MP 

PROVIDER: S-EPMC9811569 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature