Placing gold on a π⁺-surface: ligand design and impact on reactivity.

ABSTRACT: We describe a novel gold chloride complex supported by an ambiphilic phosphine/xanthylium ligand in which the AuCl moiety interacts with the π⁺ surface of the xanthylium unit as indicated by structural studies. Energy decomposition analyses carried out on a model system indicates the prevalence of non-covalent interactions in which the electrostatic and dispersion terms cumulatively dominate. The presence of these AuCl-π⁺ interactions correlates with the high catalytic activity of this complex in the cyclisation of 2-(phenylethynyl)phenylboronic acid, N-propargyl-t-butylamide, and 2-allyl-2-(2-propynyl)malonate. Comparison with the significantly less active acridinium and the 9-oxa-10-boraanthracene analogues reinforces this conclusion.

SUBMITTER: Liu WC 

PROVIDER: S-EPMC9811580 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature