Differential associations of lipoprotein(a) level with cerebral large artery and small vessel diseases.

ABSTRACT:

Background and purpose

Cerebral large artery and small vessel diseases are related to different pathogenetic mechanisms and have different risk factor profile. Lipoprotein(a) (Lp(a)) was shown to promote atherosclerosis but data was limited on its association with cerebral small vessel diseases (cSVD). The objective of this study was to assess the associations of Lp(a) level with the two types of cerebrovascular diseases.

Methods

Community-dwelling subjects aged 50-75 years from the baseline survey of The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study were included. Lp(a) concentrations was measured and categorised into three groups according to the tertiles. Eligible participants were scanned by a 3.0T MRI scanner and assessed for intracranial at

SUBMITTER: Pan Y 

PROVIDER: S-EPMC9811597 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature