Polo-like kinase 1 is related with malignant characteristics and inhibits macrophages infiltration in glioma.

ABSTRACT:

Background

Tumor immune microenvironment (TIM) plays a critical role in tumorigenesis and progression. Recently, therapies based on modulating TIM have made great breakthroughs in cancer treatment. Polo-like kinase 1 (PLK1) is a crucial regulatory factor of the cell cycle process and its dysregulations often cause various pathological processes including tumorigenesis. However, the detailed mechanisms surrounding the regulation of PLK1 on glioma immune microenvironment remain undefined.

Methods

Public databases and online datasets were used to extract data of PLK1 expression, clinical features, genetic alterations, and biological functions. The EdU, flow cytometry, and macrophage infiltration assays as well as xenograft animal experiments were performed to determine the rela

SUBMITTER: Luo L 

PROVIDER: S-EPMC9811677 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature