Regional differences of the sclera in the ocular hypertensive rat model induced by circumlimbal suture.

ABSTRACT:

Purpose

To describe the regional differences of the sclera in ocular hypertension (OHT) models with the inappropriate extension of the ocular axis.

Methods

To discover the regional differences of the sclera at the early stage, OHT models were established using circumlimbal suture (CS) or sclerosant injection (SI). Axial length (AL) was measured by ultrasound and magnetic resonance imaging. The glaucoma-associated distinction was determined by intraocular pressure (IOP) and retrograde tracing of retinal ganglion cells (RGCs). The central thickness of the ganglion cell complex (GCC) was measured by optical coherence tomography. RGCs and collagen fibrils were detected using a transmission electron microscope, furthermore, anti-alpha smooth muscle actin (αSMA) was determined in

SUBMITTER: Xia M 

PROVIDER: S-EPMC9811703 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature