PLAGL1 is associated with prognosis and cell proliferation in pancreatic adenocarcinoma.

ABSTRACT:

Background

Emerging evidence has shown the crucial roles of pleomorphic adenoma gene (PLAG) family genes in multiple cancers. However, their functions and mechanisms in pancreatic adenocarcinoma (PAAD) remain poorly understood.

Methods

We analyzed the expression levels of PLAG family genes in both The Cancer Genome Atlas (TCGA) database and a Gene Expression Omnibus (GEO) database, and confirmed the results in our three independent cohorts of 382 PAAD tissues and 362 adjacent nontumor pancreatic tissues. Integrated analyses were carried out to explore the function, mechanism and prognostic value of the selected PLAG family gene in PAAD patients.

Results

By analyzing the TCGA and GEO databases, PLAGL1 was identified to be downregulated in PAAD tissues, and its decreasi

SUBMITTER: Liang X 

PROVIDER: S-EPMC9811725 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature