Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities.

ABSTRACT: The major vascular cause of dementia is cerebral small vessel disease (SVD), including white matter hyperintensities (WMH) amongst others. While the underlying pathology of SVD remains unclear, chronic hypertension and neuroinflammation are recognized as important risk factors for SVD and for the conversion of normal-appearing white matter (NAWM) to WMH. Unfortunately, most studies investigating the role of neuroinflammation in WMH relied on peripheral blood markers, e.g., markers for systemic or vascular inflammation, as a proxy for inflammation in the brain itself. However, it is unknown whether such markers accurately capture inflammatory changes within the cerebral white matter. Therefore, we aimed to comprehensively investigate the impact of hypertension on perivascular- and neuroinfl

SUBMITTER: Sole-Guardia G 

PROVIDER: S-EPMC9811756 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature