Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice.

ABSTRACT:

Background

Ischemic stroke immediately evokes a strong neuro-inflammatory response within the vascular compartment, which contributes to primary infarct development under vessel occlusion as well as further infarct growth despite recanalization, referred to as ischemia/reperfusion injury. Later, in the subacute phase of stroke (beyond day 1 after recanalization), further inflammatory processes within the brain parenchyma follow. Whether this second wave of parenchymal inflammation contributes to an additional/secondary increase in infarct volumes and bears the potential to be pharmacologically targeted remains elusive. We addressed the role of the NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome in the subacute phase of ischemic stroke.

Methods

Focal cerebra

SUBMITTER: Bellut M 

PROVIDER: S-EPMC9811791 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature