Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes.

ABSTRACT:

Background

Congenital heart defects (CHDs) affect 40 000 US births per year, half of which require surgical intervention. Individual differences in surgical outcomes including mortality and complications are not well understood but may be due to genetic variability. We hypothesized that polygenic risk scores (PRSs) for blood pressure in adults are associated with treatments and postsurgical outcomes in children with CHD, as CHD survivors are at higher risk of negative cardiometabolic disease.

Methods

We used imputed genotype data from pediatric participants requiring surgery for CHD (median age at surgery, 201 days; n_max=2498). Base data for the systolic and diastolic blood pressure PRSs (n_max=760 226) came from published genome-wide association study.

SUBMITTER: Breeyear JH 

PROVIDER: S-EPMC9811841 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature