Multivitamin use and risk of preeclampsia: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Preeclampsia is associated with adverse maternal and neonatal outcomes. It is unclear whether multivitamin use reduces the risk of preeclampsia. This systematic review and meta-analysis aimed to evaluate the association between multivitamin use and the risk of preeclampsia.

Material and methods

We searched PubMed, Embase and the Cochrane Library from database inception to July 2021. Randomized controlled trials (RCTs), case-control and cohort studies assessing the association between multivitamin use and risk of preeclampsia were eligible. Studies of treatment with a single micronutrient were excluded. Relative risks and 95% confidence intervals (95% CI) were calculated using random-effects models. RoB2, the Newcastle Ottawa Scale and GRADE were used to assess r

SUBMITTER: Christiansen CH 

PROVIDER: S-EPMC9812096 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature