The effect of paternal and maternal factors on the prognosis of live birth in couples with recurrent pregnancy loss.

ABSTRACT:

Introduction

Currently, recurrent pregnancy loss (RPL) examinations focus on the woman, although paternal factors are also involved. Men in couples with RPL have higher sperm DNA fragmentation levels than fertile men, but the effect of sperm DNA damage on couple's later prognosis is unknown. Advanced maternal age and obesity are associated with RPL, but paternal lifestyle factors are less studied. Therefore, we aimed to study the associations of couples' lifestyle factors, causes of RPL, and sperm DNA fragmentation with their prognosis of future live birth.

Material and methods

This descriptive cohort study comprised 506 couples investigated for RPL at Helsinki University Hospital, Finland, between 2007 and 2016, linked with national health and population registers. The prim

SUBMITTER: Peuranpaa PL 

PROVIDER: S-EPMC9812203 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature