Cervical pessary and cerclage placement for preterm birth prevention and cervicovaginal microbiome changes.

ABSTRACT:

Introduction

Our objective was to compare the vaginal microbiome in low-risk and high-risk pregnant women and to explore a potential association between vaginal microbiome and preterm birth.

Material and methods

A pilot, consecutive, longitudinal, multicenter study was conducted in pregnant women at 18-22 weeks of gestation. Participants were assigned to one of three groups: control (normal cervix), pessary (cervical length ≤25 mm) and cerclage (cervical length ≤25 mm or history of preterm birth). Analysis and comparison of vaginal microbiota as a primary outcome was performed at inclusion and at 30 weeks of gestation, along with a follow-up of pregnancy and perinatal outcomes. We assessed the vaginal microbiome of pregnant women presenting a short cervix with that of pregna

SUBMITTER: Vargas M 

PROVIDER: S-EPMC9812209 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature