Neurotransmitter receptor densities are associated with changes in regional Cerebral blood flow during clinical ongoing pain.

ABSTRACT: Arterial spin labelling (ASL) plays an increasingly important role in neuroimaging pain research but does not provide molecular insights regarding how regional cerebral blood flow (rCBF) relates to underlying neurotransmission. Here, we integrate ASL with positron emission tomography (PET) and brain transcriptome data to investigate the molecular substrates of rCBF underlying clinically relevant pain states. Two data sets, representing acute and chronic ongoing pain respectively, were utilised to quantify changes in rCBF; one examining pre-surgical versus post-surgical pain, and the second comparing patients with painful hand Osteoarthritis to a group of matched controls. We implemented a whole-brain spatial correlation analysis to explore associations between change in rCBF (ΔCBF) and neu

SUBMITTER: Vamvakas A 

PROVIDER: S-EPMC9812236 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature