Regional gene expression patterns are associated with task-specific brain activation during reward and emotion processing measured with functional MRI.

ABSTRACT: The exploration of the spatial relationship between gene expression profiles and task-evoked response patterns known to be altered in neuropsychiatric disorders, for example depression, can guide the development of more targeted therapies. Here, we estimated the correlation between human transcriptome data and two different brain activation maps measured with functional magnetic resonance imaging (fMRI) in healthy subjects. Whole-brain activation patterns evoked during an emotional face recognition task were associated with topological mRNA expression of genes involved in cellular transport. In contrast, fMRI activation patterns related to the acceptance of monetary rewards were associated with genes implicated in cellular localization processes, metabolism, translation, and synapse regula

SUBMITTER: Komorowski A 

PROVIDER: S-EPMC9812247 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature