Differential modulation of endothelial cytoplasmic protrusions after exposure to graphene-family nanomaterials.

ABSTRACT: Engineered nanomaterials offer the benefit of having systematically tunable physicochemical characteristics (e.g., size, dimensionality, and surface chemistry) that highly dictate the biological activity of a material. Among the most promising engineered nanomaterials to date are graphene-family nanomaterials (GFNs), which are 2-D nanomaterials (2DNMs) with unique electrical and mechanical properties. Beyond engineering new nanomaterial properties, employing safety-by-design through considering the consequences of cell-material interactions is essential for exploring their applicability in the biomedical realm. In this study, we asked the effect of GFNs on the endothelial barrier function and cellular architecture of vascular endothelial cells. Using micropatterned cell pairs as a reductio

SUBMITTER: Ardona HAM 

PROVIDER: S-EPMC9812361 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature