Amoxicillin Did Not Reduce Modic Change Edema in Patients With Chronic Low Back Pain: Subgroup Analyses of a Randomised Trial (the AIM Study).

ABSTRACT:

Study design

Exploratory subgroup analyses of a randomised trial [Antibiotics in Modic changes (AIM) study].

Objective

The aim was to assess the effect of amoxicillin versus placebo in reducing Modic change (MC) edema in patients with chronic low back pain.

Summary of background data

The AIM study showed a small, clinically insignificant effect of amoxicillin on pain-related disability in patients with chronic low back pain and MC type 1 (edema type) on magnetic resonance imaging (MRI).

Materials and methods

A total of 180 patients were randomised to receive 100 days of amoxicillin or placebo. MC edema was assessed on MRI at baseline and one-year follow-up. Per-protocol analyses were conducted in subgroups with MC edema on short tau inversion recovery (STIR) or

SUBMITTER: Kristoffersen PM 

PROVIDER: S-EPMC9812422 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature