Global transcriptional responses of pneumococcus to human blood components and cerebrospinal fluid.

ABSTRACT: Streptococcus pneumoniae (pneumococcus) is a leading cause of severe invasive infectious diseases such as sepsis and meningitis. Understanding how pneumococcus adapts and survive in the human bloodstream environment and cerebrospinal fluid (CSF) is important for development of future treatment strategies. This study investigates the global transcriptional response of pneumococcus to human blood components and CSF acquired from discarded and anonymized patient samples. Extensive transcriptional changes to human blood components were observed during early stages of interaction. Plasma-specific responses were primarily related to metabolic components and include strong downregulation of fatty acid biosynthesis genes, and upregulation of nucleotide biosynthesis genes. No transcriptional

SUBMITTER: Pettersen JS 

PROVIDER: S-EPMC9812572 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature