Performance of Restricted Mean Survival Time Based Methods and Traditional Survival Methods: An Application in an Oncological Data

ABSTRACT:

Objective

To compare restricted mean survival time- (RMST-) based methods with traditional survival methods when multiple covariates are of interest.

Methods

4405 osteosarcomas were captured from Surveillance, Epidemiology, and End Results Program Database. RMST-based methods included group comparison using Kaplan-Meier (KM) method, pseudovalue (PV) regression, and inverse probability of censoring probability (IPCW) regressions with group-specific and individual weights. Log-rank test, Wilcoxon test, Cox regression, and its extension with time-dependent variables were selected as traditional methods. Proportional hazard (PH) assumption and homogeneity of censoring mechanism assumption were assessed. We estimated hazard ratio (HR) and difference in RMST and explored thei

SUBMITTER: Huang Q 

PROVIDER: S-EPMC9812622 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature