A Case-Control Study of the Association of Leptin Gene Polymorphisms with Plasma Leptin Levels and Obesity in the Kerala Population.

ABSTRACT:

Background

Over the last few years, the importance of leptin in energy metabolism has been extensively studied in both animal models and in humans. Very few results are available on the association between human leptin gene (LEP) variants and obesity traits in India. We designed this study to analyse the polymorphisms in human leptin gene and the association of sequence variants with obesity among the population in Kerala, South India.

Methods

In this case-control design of 148 study participants, data were collected on socioeconomic aspects and anthropometric measurements. Plasma glucose, insulin, leptin, and lipid profile were measured. Genotyping was done by automated DNA sequencing.

Results

The common Single Nucleotide Polymorphism (SNP) of 5'-UTR of LEP

SUBMITTER: Manju SK 

PROVIDER: S-EPMC9812639 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature