Cortical-hippocampal coupling during manifold exploration in motor cortex.

ABSTRACT: Systems consolidation-a process for long-term memory stabilization-has been hypothesized to occur in two stages^1-4. Whereas new memories require the hippocampus^5-9, they become integrated into cortical networks over time^10-12, making them independent of the hippocampus. How hippocampal-cortical dialogue precisely evolves during this and how cortical representations change in concert is unknown. Here, we use a skill learning task^13,14 to monitor the dynamics of cross-area coupling during non-rapid eye movement sleep along with changes in primary motor cortex (M1) representational stability. Our results indicate that precise cross-area coupling between hippocampus, prefrontal cortex and M1 can demarcate two distinct stages of processing. We specifi

SUBMITTER: Kim J 

PROVIDER: S-EPMC9812770 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature