Targeting the "hallmarks of aging" to slow aging and treat age-related disease: fact or fiction?

ABSTRACT: Aging is a major risk factor for a number of chronic diseases, including neurodegenerative and cerebrovascular disorders. Aging processes have therefore been discussed as potential targets for the development of novel and broadly effective preventatives or therapeutics for age-related diseases, including those affecting the brain. Mechanisms thought to contribute to aging have been summarized under the term the "hallmarks of aging" and include a loss of proteostasis, mitochondrial dysfunction, altered nutrient sensing, telomere attrition, genomic instability, cellular senescence, stem cell exhaustion, epigenetic alterations and altered intercellular communication. We here examine key claims about the "hallmarks of aging". Our analysis reveals important weaknesses that preclude strong and d

SUBMITTER: Keshavarz M 

PROVIDER: S-EPMC9812785 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature