Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan-cancer analysis.

ABSTRACT: Telomerase activation is required for malignant transformation. Recent advances in high-throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensively, which has proven to be challenging due to the need for laborious assays required to test for telomerase activity. To solve these issues, several groups have analyzed TCGA pan-cancer tumor datasets by investigating telomerase reverse transcriptase (TERT), the catalytic subunit for telomerase activity, or its surrogates. However, telomerase is a multiunit complex containing not only TERT, but also numerus cofactors required for telomerase function. Here we determined genomic and molecular alterations of 10 well-characterized telomerase compone

SUBMITTER: Wang J 

PROVIDER: S-EPMC9812836 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature