Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer.

ABSTRACT:

Purpose

Diffuse gastric cancer (DGC) is an aggressive and frequently lethal subtype of gastric cancer. Because DGC often lacks genomic aberrations that indicate clear candidate therapeutic targets, it has been challenging to develop targeted therapies for this gastric cancer subtype. Our previous study highlighted the contribution of focal adhesion kinase (FAK) in the tumorigenesis of DGC and the potential efficacy of small-molecule FAK inhibitors. However, drug resistance to monotherapy often hinders the efficacy of treatment.

Experimental design

We generated a genome-scale library of open reading frames (ORF) in the DGC model of Cdh1-/-RHOAY42C/+ organoids to identify candidate mechanisms of resistance to FAK inhibition. Compensatory activated pathways were also detected f

SUBMITTER: Peng K 

PROVIDER: S-EPMC9812865 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature