Estrogen depletion modulates aortic prothrombotic signaling in normotensive and spontaneously hypertensive female rats.

ABSTRACT:

Aim

In this study, we investigated how platelets and aorta contribute to the creation and maintenance of a prothrombotic state in an experimental model of postmenopausal hypertension in ovariectomized rats.

Methods

Bilateral ovariectomy was performed in both 14-week-old female spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats. The animals were kept in phytoestrogen free diet. Vascular parameters, platelet, coagulation and aortic prothrombotic functions and mechanisms were assessed.

Results

Exacerbated platelet aggregation was observed in both SHR and WKY animals after ovariectomy. The mechanism was related to aortic COX2 downregulation and reduction in AMP, ADP, and ATP hydrolysis in serum and platelets. A procoagulant potential was observed in

SUBMITTER: Pizzato SB 

PROVIDER: S-EPMC9812894 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature