Ontology highlight
ABSTRACT: Significance
Translatome analysis in medulloblastoma shows that N-myc drives selective translation of transcripts that promote protein homeostasis and that represent new therapeutic vulnerabilities.
SUBMITTER: Kuzuoglu-Ozturk D
PROVIDER: S-EPMC9812901 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Cancer research 20230101 1
Deregulation of neuroblastoma-derived myc (N-myc) is a leading cause of malignant brain tumors in children. To target N-myc-driven medulloblastoma, most research has focused on identifying genomic alterations or on the analysis of the medulloblastoma transcriptome. Here, we have broadly characterized the translatome of medulloblastoma and shown that N-myc unexpectedly drives selective translation of transcripts that promote protein homeostasis. Cancer cells are constantly exposed to proteotoxic ...[more]