N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.

ABSTRACT: Deregulation of neuroblastoma-derived myc (N-myc) is a leading cause of malignant brain tumors in children. To target N-myc-driven medulloblastoma, most research has focused on identifying genomic alterations or on the analysis of the medulloblastoma transcriptome. Here, we have broadly characterized the translatome of medulloblastoma and shown that N-myc unexpectedly drives selective translation of transcripts that promote protein homeostasis. Cancer cells are constantly exposed to proteotoxic stress associated with alterations in protein production or folding. It remains poorly understood how cancers cope with proteotoxic stress to promote their growth. Here, our data revealed that N-myc regulates the expression of specific components (∼5%) of the protein folding machinery at the transla

SUBMITTER: Kuzuoglu-Ozturk D 

PROVIDER: S-EPMC9812901 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature