Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients With Antiphospholipid Syndromes: Meta-Analysis of Randomized Trials.

ABSTRACT:

Background

The efficacy and safety of direct oral anticoagulants (DOACs) for patients with thrombotic antiphospholipid syndrome remain controversial.

Objectives

The authors performed a systematic review and meta-analysis of randomized controlled trials that compared DOACs with vitamin K antagonists (VKAs).

Methods

We searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials through April 9, 2022. The 2 main efficacy outcomes were a composite of arterial thrombotic events and venous thromboembolic events (VTEs). The main safety outcome was major bleeding. Random effects models with inverse variance were used.

Results

Our search retrieved 253 studies. Four open-label randomized controlled trials involving 472 patients were included (mean control

SUBMITTER: Khairani CD 

PROVIDER: S-EPMC9812926 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature