Real-world effectiveness, long-term safety and treatment pathway integration of radium-223 therapy in patients with metastatic castration-resistant prostate cancer.

ABSTRACT: Radium-223 dichloride (²²³Ra) is an α-emitter approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC) with bone metastases, but without visceral involvement. Despite being a life-prolonging therapy (LPT), ²²³Ra remains underutilized. A large body of real-world evidence (RWE) for ²²³Ra has been published in the decade since the pivotal phase 3 ALSYMPCA study, a period during which the treatment landscape has continued to evolve. How to optimize ²²³Ra use, including how to integrate it into the mCRPC management pathway amongst other current LPTs (i.e., with respect to timing and concurrent, layered, or sequential use), is therefore of considerable interest. RWE studies lack the conventional restraints of clinical trial

SUBMITTER: O'Sullivan JM 

PROVIDER: S-EPMC9812947 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature