Acetyl-DL-leucine in cerebellar ataxia ([¹⁸F]-FDG-PET study): how does a cerebellar disorder influence cortical sensorimotor networks?

ABSTRACT:

Objective

The aim of the study was to deepen our insights into central compensatory processes of brain networks in patients with cerebellar ataxia (CA) before and with treatment with acetyl-DL-leucine (AL) by means of resting-state [¹⁸F]-FDG-PET brain imaging.

Methods

Retrospective analyses of [¹⁸F]-FDG-PET data in 22 patients with CA (with vestibular and ocular motor disturbances) of different etiologies who were scanned before (PET A) and on AL treatment (PET B). Group subtraction analyses, e.g., for responders and non-responders, comparisons with healthy controls and correlation analyses of regional cerebral glucose metabolism (rCGM) with symptom duration, ataxia (SARA) and quality of life (QoL) scores were calculated.

Results

Prior to treatme

SUBMITTER: Becker-Bense S 

PROVIDER: S-EPMC9813104 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature