The association of serum immunoglobulins with cognition and dementia: the Rotterdam Study.

ABSTRACT:

Background

Chronic inflammation is involved in the pathophysiology of dementia, but the association of serum immunoglobulins with dementia has been understudied and longitudinal data are currently lacking. We investigated the association of serum immunoglobulin (Ig) A, G, and M with cognition and dementia in a population-based cohort.

Methods

This study was embedded in the Rotterdam Study. Participants with information on serum immunoglobulin levels, measured between 1997 and 2009, were followed for incident dementia until 2016. Assessment of cognitive function and dementia was performed according to validated tests and clinical criteria respectively. We studied the association between serum immunoglobulins with prevalent and incident dementia using logistic regression and C

SUBMITTER: Khan SR 

PROVIDER: S-EPMC9813113 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature