Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma.

ABSTRACT: Lactic acidosis has been reported in solid tumor microenvironment (TME) including glioblastoma (GBM). In TME, several signaling molecules, growth factors and metabolites have been identified to induce resistance to chemotherapy and to sustain immune escape. In the early phases of the disease, microglia infiltrates TME, contributing to tumorigenesis rather than counteracting its growth. Insulin-like Growth Factor Binding Protein 6 (IGFBP6) is expressed during tumor development, and it is involved in migration, immune-escape and inflammation, thus providing an attractive target for GBM therapy. Here, we aimed at investigating the crosstalk between lactate metabolism and IGFBP6 in TME and GBM progression. Our results show that microglia exposed to lactate or IGFBP6 significantly increased the

SUBMITTER: Longhitano L 

PROVIDER: S-EPMC9813126 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature