Freezing of gait is a risk factor for cognitive decline in Parkinson's disease.

ABSTRACT:

Backgrounds

Freezing of gait (FOG) and cognitive impairment are serious symptoms of Parkinson's disease (PD). Understanding the association between FOG and cognition may help formulate specific interventions for PD individuals.

Objectives

We aimed to investigate the associations of cognitive impairment in different domains with FOG status using multiple neuropsychological tests.

Methods

Two cohorts including 691 and 104 participants were recruited from Parkinson's progression markers initiative (PPMI) and central China, respectively. All participants underwent FOG assessment and neuropsychological tests, and 595 individuals from PPMI and 51 from central China were enrolled for longitudinal observation. Cross-sectional and longitudinal associations between cognition an

SUBMITTER: Qu Y 

PROVIDER: S-EPMC9813160 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature