Intratumoral T cell depletion following neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer is associated with poor clinical outcome.

ABSTRACT:

Background

Whereas neoadjuvant cisplatin-based chemotherapy (NAC) followed by a radical cystectomy remains the standard treatment for patients with muscle-invasive bladder cancer (MIBC), increasing evidence suggests that checkpoint inhibitors, either alone or in combination with chemotherapy, are effective in the (neo)adjuvant setting. The major aim of this study was to improve our understanding of the immune-modulating effects of NAC in MIBC.

Methods

Tumor tissue of 81 patients was used, including 60 patients treated with NAC and 21 patients undergoing upfront cystectomy. Multiplex immunohistochemistry was performed to assess CD3⁺, CD3⁺CD8⁺, CD3⁺CD8^-FoxP3^-, CD3⁺FoxP3⁺, and CD20⁺

SUBMITTER: van Wilpe S 

PROVIDER: S-EPMC9813168 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature