Correlation between clinical phenotype and electromyographic parameters in amyotrophic lateral sclerosis.

ABSTRACT:

Introduction

Even if electromyography (EMG) is routinely used to confirm the diagnosis of amyotrophic lateral sclerosis (ALS), few studies have analysed the correlation between electrophysiological parameters and clinical characteristics of ALS. We assessed if the quantification of active denervation (AD) and chronic denervation (CD) provides clinicians with information about phenotype, disease progression and survival in ALS patients.

Methods

We studied a cohort of 689 ALS patients recording the following parameters: age and site of onset, survival, MRC scale for muscle strength evaluation, burden of upper and lower motor signs as measured with specific scales (PUMNS and LMNS, respectively), ALSFRS-R, progression rate (ΔFS), MITOS and King's Staging systems (KSS). We perfor

SUBMITTER: Colombo E 

PROVIDER: S-EPMC9813173 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature