Monogenic diabetes clinic (MDC): 3-year experience.

ABSTRACT:

Aim

In the pediatric diabetes clinic, patients with type 1 diabetes mellitus (T1D) account for more than 90% of cases, while monogenic forms represent about 6%. Many monogenic diabetes subtypes may respond to therapies other than insulin and have chronic diabetes complication prognosis that is different from T1D. With the aim of providing a better diagnostic pipeline and a tailored care for patients with monogenic diabetes, we set up a monogenic diabetes clinic (MDC).

Methods

In the first 3 years of activity 97 patients with non-autoimmune forms of hyperglycemia were referred to MDC. Genetic testing was requested for 80 patients and 68 genetic reports were available for review.

Results

In 58 subjects hyperglycemia was discovered beyond 1 year of age (Group 1) and in 1

SUBMITTER: Rapini N 

PROVIDER: S-EPMC9813184 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature