CCR7/dendritic cell axis mediates early bacterial dissemination in Orientia tsutsugamushi-infected mice.

ABSTRACT: Scrub typhus is a life-threatening zoonosis caused by the obligate intracellular bacterium Orientia tsutsugamushi (Ot) that is transmitted by the infected larvae of trombiculid mites. However, the mechanism by which Ot disseminates from the bite site to visceral organs remains unclear; host innate immunity against bacterial dissemination and replication during early infection is poorly understood. In this study, by using an intradermal infection mouse model and fluorescent probe-labeled Ot, we assessed the dynamic pattern of innate immune cell responses at the inoculation site. We found that neutrophils were the first responders to Ot infection and migrated into the skin for bacterial uptake. Ot infection greatly induced neutrophil activation, and

SUBMITTER: Liang Y 

PROVIDER: S-EPMC9813216 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature