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Costunolide alleviates atherosclerosis in high-fat diet-fed ApoE^-/- mice through covalently binding to IKKβ and inhibiting NF-κB-mediated inflammation.

ABSTRACT: Costunolide (CTD) is a sesquiterpene lactone isolated from costus root and exhibits various biological activities including anti-inflammation. Since atherosclerosis is a chronic inflammatory disease, we herein investigated the anti-atherosclerotic effects of CTD and the underlying mechanism. Atherosclerosis was induced in ApoE^-/- mice by feeding them with a high-fat diet (HFD) for 8 weeks, followed by administration of CTD (10, 20 mg ·kg^-1·d^-1, i.g.) for 8 weeks. We showed that CTD administration dose-dependently alleviated atherosclerosis in HFD-fed ApoE^-/- mice. Furthermore, we found that CTD dose-dependently reduced inflammatory responses in aortas of the mice, as CTD prevented infiltration of inflammatory cells in aortas and attenuated oxLDL

SUBMITTER: Huang ZQ

PROVIDER: S-EPMC9813247 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Dataset Information

Costunolide alleviates atherosclerosis in high-fat diet-fed ApoE^-/- mice through covalently binding to IKKβ and inhibiting NF-κB-mediated inflammation.

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Dataset Information

Costunolide alleviates atherosclerosis in high-fat diet-fed ApoE-/- mice through covalently binding to IKKβ and inhibiting NF-κB-mediated inflammation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Costunolide alleviates atherosclerosis in high-fat diet-fed ApoE^-/- mice through covalently binding to IKKβ and inhibiting NF-κB-mediated inflammation.