Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness.

ABSTRACT: Obesity increases asthma prevalence and severity. However, the underlying mechanisms are poorly understood, and consequently, therapeutic options for asthma patients with obesity remain limited. Here we report that cholecystokinin-a metabolic hormone best known for its role in signaling satiation and fat metabolism-is increased in the lungs of obese mice and that pharmacological blockade of cholecystokinin A receptor signaling reduces obesity-associated airway hyperresponsiveness. Activation of cholecystokinin A receptor by the hormone induces contraction of airway smooth muscle cells. In vivo, cholecystokinin level is elevated in the lungs of both genetically and diet-induced obese mice. Importantly, intranasal administration of cholecystokinin A receptor antagonists (proglumide and devaz

SUBMITTER: Panganiban RAM 

PROVIDER: S-EPMC9813361 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature