The prevalence and outcomes of frail older adults in clinical trials in multiple myeloma: A systematic review.

ABSTRACT: Multiple myeloma (MM) is an incurable blood cancer that primarily affects older adults. Several frailty tools have been developed to address the heterogeneity of aging in this population. Uptake of these measures has been variable, leading to a gap in knowledge regarding the proportion of enrolled trial participants considered frail and uncertainty in the treatment-related effects and outcomes among this high-risk population. We performed a systematic review of therapeutic interventional MM clinical trials reporting on frailty. We included 43 clinical trials (24 randomized controlled trials and 19 non-randomized trials) which met eligibility criteria. Frailty was increasingly incorporated in studies in more recent years with 41.9% of included studies being reported in the last two years. C

SUBMITTER: Mian H 

PROVIDER: S-EPMC9813365 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature