Topological implications of DNA tumor viral episomes.
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ABSTRACT:
SUBMITTER: Kim ET
PROVIDER: S-EPMC9813422 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
Topological implications of DNA tumor viral episomes.
Kim Eui Tae ET Kim Kyoung-Dong KD
BMB reports 20221201 12
A persistent DNA tumor virus infection transforms normal cells into cancer cells by either integrating its genome into host chromosomes or retaining it as an extrachromosomal entity called episome. Viruses have evolved mechanisms for attaching episomes to infected host cell chromatin to efficiently segregate the viral genome during mitosis. It has been reported that viral episome can affect the gene expression of the host chromosomes through interactions between viral episomes and epigenetic reg ...[more]
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